DUBAI, United Arab Emirates (AP) — The U.S. and Israel launched a major attack on Iran on Saturday, and President Donald Trump called on the Iranian public to “seize control of your destiny” by rising up against the Islamic leadership that has ruled the nation since 1979.
Some of the first strikes appeared to hit areas around the offices of Supreme Leader Ayatollah Ali Khamenei, and Iranian media reported strikes nationwide. Smoke could be seen rising from the capital. It wasn’t immediately clear whether the 86-year-old leader was in his offices at the time of the strike.
“When we are finished, take over your government. It will be yours to take. This will be probably your only chance for generations,” Trump said in a video announcing “major combat operations” were underway. “For many years, you have asked for America’s help, but you never got it.”
Israeli Prime Minister Benjamin Netanyahu echoed that sweeping goal. “Our joint operation will create the conditions for the brave Iranian people to take their fate into their own hands,” Netanyahu said.
The strikes opened a stunning new chapter in U.S. intervention in Iran and marked the second time in eight months that the Trump administration has used military force against the Islamic Republic. They also came just weeks after Trump ordered a military operation to capture Venezuela’s president, Nicolás Maduro, and bring him and his wife to New York to face federal drug conspiracy charges.
The targets included members of Iran’s leadership, according to a U.S. official and another person briefed on the attacks who both spoke on condition of anonymity because they were discussing classified information on an ongoing operation. There was no immediate information on whether top officials had been killed.
Tensions have soared in recent weeks as American warships moved into the region. Trump said he wanted a deal to constrain Iran’s nuclear program at a moment when the country is struggling at home with growing dissent following nationwide protests.
The immediate trigger for Saturday’s strikes appears to be the unsuccessful latest round of nuclear talks. But they also reflect the dramatic changes across the region that have left Iran’s leadership in its weakest position since the Islamic Revolution nearly half a century ago.
Israeli and American strikes last June greatly weakened Iran’s air defenses, military leadership and nuclear program. A regionwide war, sparked by Hamas’ Oct. 7, 2023, attack on Israel, has left Iran’s network of proxies across the Middle East greatly weakened. U.S. sanctions and global isolation, meanwhile, have decimated Iran’s economy.
Iran responded to the latest strikes as it had been threatening to do for months — first launching a wave of missiles and drones targeting Israel. It followed with strikes targeting U.S. military installations in Bahrain, Kuwait and Qatar. The United Arab Emirates and Iraq shut down their airspace.
Iran’s Foreign Ministry issued a defiant statement, saying the country “will not hesitate” in its response. In a statement posted on X, the ministry said: “The time has come to defend the homeland and confront the enemy’s military assault.”
At least 57 people were reported killed at a girls’ school in southern Iran in the Israeli-U.S. strikes, according to Iran’s state-run IRNA news agency. At least 45 others were wounded in the attack in Minab in Iran’s Hormozgan province. The White House and the Israeli military did not immediately respond to a request for comment on reported strike on the school.
In an indication of the scope of the conflict, flights across the Middle East were disrupted and air defense fire thudded over Dubai, the commercial capital of the United Arab Emirates, Saturday afternoon. Associated Press journalists saw the aftereffects of the blast from an interceptor.
Shrapnel from an Iranian missile attack on the capital of the UAE killed one person, state media said.
Attack was coordinated between Israel and US
The U.S. military has for weeks amassed forces in the region, even as U.S. and Iranian envoys held talks in Switzerland and Oman aimed at finding a diplomatic solution.
“Active and serious negotiations have yet again been undermined,” Oman’s Foreign Minister Badr al-Busaidi said in a post on X. Al-Busaidi, a key mediator in the nuclear talks, traveled to Washington on Friday to meet with Vice President JD Vance.
